The Archdiocesan Shrine of Santo Niño de Midsayap is the parish and archdiocesan shrine located in Midsayap, North Cotabato. It is under the ecclesiastical jurisdiction of the Roman Catholic Archdiocese of Cotabato. Santo Niño Parish is the oldest parish church established by the missionary congregation of the Oblates of Mary Immaculate in 1939.

The pioneering OMI priests took over the missionary territory of Cotabato which includes Midsayap which during that time covers Midsayap, Libungan, Pigcawayan, Alamada and Aleosan. It was initiated by a French-Canadian Oblate priest, Rev. Fr. Egide Beaudin, OMI to fortify the evangelization of Christian settlers in the locality who were mostly coming from Visayas and Luzon who dreamed of living in Mindanao - the so-called Land of Promise. Fr. Beaudin made frequent contacts with the faithfuls where in just a few months of his work, he was able to learn the Cebuano language, earning him as a lovable and jubilant fatherly figure. Fr. Gil as he was fondly called by the people, Beaudin got enormous help from the people which made it possible to construct a worship place earnestly dedicated to the Child Jesus to whom most Cebuano settlers adored from their hometown of Cebu where He is highly revered. They were able to celebrate their first ever fiesta immediately to highlight the success of completing the church.

Fr. Beaudin was given full support by fellow missionaries to continue the missionary zeal of spreading the Gospel even to the harshest stations such as Cotabato populated my majority Muslim and Islam adhering Filipinos.
When the Second World War broke in 1941, the flourishing mission parish of Santo Niño was closed as worldwide turmoil reached Mindanao by invading Japanese forces. Foreign missionaries including the Oblates were put to concentration camps in the University of Santo Tomas and the University of the Philippines in Los Baños, Laguna.