De Rose of Manila had its humble beginnings in 1963 at Quiapo, Manila. It started out as a general merchandise store with glassware, beauty and school supplies and grocery items as its first product lines.
20 years after, in 1983 it opened its first store outside of Manila. This was in Midsayap, Cotabato. In the 1990s, it continued to expand by opening stores in Palawan and Boracay.
The De Rose shopping center in Midsayap has become the prime store of the company having three adjacent buildings found in the central business district of Midsayap town.
In 2013, De Rose of Midsayap celebrated its 30 years of continued service and excellence in Midsayap with excellent products and services at its departments store, Supermarket, Fonekits, Pharmacy

, Bakeshop, Foodcourt and Kalye Kainan.